6 edition of Molecular and cellular biology of pharmacological targets found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Hartmut Glossmann and Jörg Striessnig.|
|Series||Methods in pharmacology ;, v. 7|
|Contributions||Glossmann, H., Striessnig, Jörg.|
|LC Classifications||QP905 .M45 vol. 7, QH603.I54 .M45 vol. 7|
|The Physical Object|
|Pagination||x, 277 p. :|
|Number of Pages||277|
|LC Control Number||93005645|
2. be able to discuss the molecular pharmacology of receptors, channels and enzymes 3. have gained a knowledge of molecular biology techniques used in pharmacology 4. be able to accurately record experimental data and draw conclusions from experimental data 5. be able to demonstrate their ability to work in teams and communicateFile Size: KB. Preface ix Abbreviations x 1 Introduction to Drug Targets and Molecular Pharmacology 1 Introduction to molecular pharmacology 1 Scope of this textbook 2 The nature of drug targets 3 Future drug targets 7 Molecular pharmacology and drug discovery 11 References 12 2 Molecular Cloning of Drug Targets 13 Introduction to molecular cloning from DNA to drug 4/5(1). With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics.5/5(1). In biology, the same concept, called network biology, can be applied, connecting several entities at the molecular, cellular, pathways or more complex levels to decipher a phenotype, a disease, or any kind of biological outcome of interest. To develop network biology, the interactions between the different components have to be organized and Cited by:
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Methods in Pharmacology Molecular and Cellular Biology of Pharmacological Targets. Editors: Glossmann, H., Striessnig, J. (Eds.) Free Preview. Buy this book eBook ,49 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free. ISBN: OCLC Number: Description: x, pages: illustrations ; 26 cm.
Contents: Purification and pharmacological analysis of the omega-conotoxin GVIA receptor from rat brain / Maureen W. McEnery --Molecular characterization of the charybdotoxin-sensitive, high-conductance, calcium-activated potassium channel / Margarita Garcia-Calvo, Gregory J.
Kaczorowski. Get this from a library. Methods in Pharmacology: Molecular and Cellular Biology of Pharmacological Targets.
[H Glossmann; Jörg Striessnig] -- The current volume provides detailed experimental protocols used to study plasma membrane ion channels as pharmacological targets. Coverage includes molecular and biochemical characterization of ion. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain.
The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.
Drawing on the latest research in this dynamic field, author Lauren Pecorino makes cutting-edge science readily by: Terry P. Kenakin, in Pharmacology in Drug Discovery and Development (Second Edition), Pharmacological Targets. The term “ pharmacological target ” refers to the biochemical entity to which the drug first binds in the body to elicit its effect.
There are a number of such entities targeted by drug molecules. In general, they can be proteins, such as receptors, enzymes, transporters. Stephen L. Wolfe [U of California, Davis (Ph.D., Johns Hopkins University)] taught general biology and cell biology for many years at the University of California, Davis.
His textbooks include multiple editions of Biology of the Cell, Biology: The Foundations, Cell Ultrastructure, Molecular and Cellular Biology, and Introduction to Cell and 4/5(1). This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology.
Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body.3/5(1).
At the molecular level, the biological and pharmacological activities of melatonin are attributed to the inhibition of nuclear factor-κappa beta (NF-κB), c-Fos over expression and down. A valuable, new source, Molecular Medical Parasitology is the only text of its kind -- one that applies broad concepts and current scientific advances from both molecular biology and biochemistry to the study of parasitic organisms.
An internationally renowned team of scientists and physicians places parasites in their broad biological contexts. The role of cell biology in unraveling disease mechanisms is well established, but the value of cell biology in drug development is less well appreciated. Cell and molecular biologists currently play a role during the earliest preclinical stages of drug development in the identification and evaluation of potential drug targets (Figure 1).Cited by: The neuropathology of Alzheimer's Disease, Esiri 3.
Molecular genetics of Alzheimer's Disease, Wasco 4. The biology and molecular neuropathology of B-amyloid protein, Howlett, Allsop and Karran 5.
The molecular basis of Tau protein pathology in Alzheimer's Disease and related neurodegenerative dementias, Wischik, Theuring and Harrington 6. Ideal for courses in the molecular biology of cancer and cancer biology, The Molecular Biology of Cancer, Second Edition, is an invaluable resource for any student wishing to gain insight into the molecular basis of the disease and formulate possible solutions for its effective control.
New to this Edition. An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students.
With the A-Z format of over 2, entries, around authors provide a complete. Molecular pharmacology is the use of molecular biology techniques to develop solutions to pharmacology questions.
Read on to learn more about the field. Inside Molecular Pharmacology. An essential text, this is a fully updated second edition of a classic, now in two volumes.
It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2, entries, around authors provide a complete reference to the area of molecular pharmacology.
Molecular Pharmacology Group The aim of our research is to study the function of receptors and transporters at the molecular level, and to develop novel pharmacological tool compounds. Increasingly, we are also studying the function of selected ligands and targets ex vivo and in vivo using animal models and genetically modified mice.
Journal of Cellular and Molecular Pharmacology aims to promote clinical and translational research on drug design, development and delivery that can effectively address the disorders and challenges at the cellular and molecular level, which may turn chronic if unattended at the formative stages.
Journal of Cellular and Molecular Pharmacology caters to the diversified needs of pharmacists. With the A-Z format of over 2, entries, around authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects.
Title: 5-Lipoxygenase: Cellular Biology and Molecular Pharmacology VOLUME: 1 ISSUE: 1 Author(s):Oliver Werz Affiliation:Institute of Pharmaceutical Chemistry, University of Frankfurt, Marie-Curie-Str.
9, D Frankfurt, Germany Keywordslipoxygenase, 5-lipoxygenase-activating protein, leukotriene, arachidonic acid, polymorphonuclear leukocytes, mitogen activated protein kinase. A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or es of common classes of biological targets are proteins and nucleic definition is context-dependent, and can refer to the biological target of a pharmacologically active drug.
Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); Top results in this book Table of Contents. Biology of T Cells - Part B, Volumethe latest release in the International Review of Cell and Molecular Biology series, offers an overview of the major molecular and cellular aspects of T-cell biology and their links to human pathophysiology.
Chapters in this release include Metabolism of T lymphocytes in health and disease, T lymphocytes and autoimmunity, Cancer immunosurveillance by T.
“An informative, comprehensive text, it is highly recommended to postgraduates and researchers in both pharmacology and molecular biology.” (Science Progress, 1 March )“Overall, it could be the basis of an excellent course for junior pharmacologists in basic science research who need a greater focus on the mechanisms of drug action rather than an encyclopedic survey of clinical drug.
Pharmacology is the branch of pharmaceutical sciences which is concerned with the study of drug or medication action, where a drug can be broadly or narrowly defined as any man-made, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharmacon is used as a term to encompass MeSH Unique ID: D Molecular pharmacology is used to investigate cloned receptors and transporters, including their interaction with ligands and their molecular mechanism-of-action.
Usually we apply a combination of techniques such as molecular biology (e.g. cloning and mutagenesis), cell culture and pharmacological assays (e.g. concentration-response curves and. Introduction to molecular pharmacology 1. Scope of this textbook 2.
The nature of drug targets 3. Future drug targets 7. Molecular pharmacology and drug discovery References 2 Molecular Cloning of Drug Targets Introduction to molecular cloning – from DNA to drug discovery ‘Traditional Author: John Dickenson.
There are a number of virus-specific processes within the virus replicative cycle or virus-infected cell that have proven to be attractive targets for chemotherapeutic intervention, i.e., virus adsorption and entry into the cells, reverse (RNA → DNA) transcription, viral DNA polymerization, and cellular enzymatic reactions that are associated with viral DNA and RNA synthesis and viral mRNA Cited by: pharmacology.
Research in these areas is pursued at the molecular, cellular, organ-system, and whole-organism levels of investigation using state-of-the-art techniques and instrumentation.
Admission and Degree Requirements • MS in Cellular and Molecular Pharmacology (See listing for PhD in Cellular and Molecular Pharmacology). Download molecular biology of neurodegenerative diseases or read online books in PDF, EPUB, Tuebl, and Mobi Format.
Click Download or Read Online button to get molecular biology of neurodegenerative diseases book now. This site is like a library, Use search box in the widget to get ebook that you want. Molecular Biology Of Neurodegenerative. Laboratory Research examines the interactions between antiinfective agents (mainly antibiotics) and eucaryotic cells within a context of cellular and molecular pharmacology and toxicology.
Disciplines and methodologies used span from Biophysics and Cellular and Molecular Biology to. ISSN: (Print) This journal supports open access.
Impact Factor: Ranking and Category. th of in. Biochemistry & Molecular Biology. th of in. Pharmacology & Pharmacy. Order Your Article Before Print. Become a Section Editor. Become a Reviewer.
Join Editorial Board. Submit Book Proposal. Join as Executive Guest Editor. Kobilka is the Hélène Irwin Fagan Chair in Cardiology and a Professor in the Department of Molecular and Cellular Physiology at Stanford University. He is a co-recipient of the Nobel Prize in Chemistry (together with his postdoctoral mentor, Prof.
Robert Lefkowitz) for their studies of G protein-coupled receptors. Trained initially as a physician at the Yale University School of.
Vol. 77, Issue 4. Decem More from Molecular Cell. Anniversary Issue. 20 years of shaping molecular biology. Tweets by @MolecularCell. Introducing Cell. Latest Articles.
Subject Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells. Tengfei Bian, Abderrahmane Tagmount, Christopher Vulpe, Kavitha Chandagirikoppal Vijendra and Chengguo Xing.
Molecular Pharmacology May 3,mol; DOI. There is a bidirectional relationship between depression and type 2 diabetes (T2D). Patients with comorbid depression and T2D are at high risk of complications and premature mortality. Conventional treatments for depression do not consistently improve diabetes outcomes, despite improving depressive symptoms.
Shared mechanisms may underpin both depression and T2D, providing novel. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain.
The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. cellular aspects of drugs, drug targets, chemical mediators, pharmacological parameters and will address drugs affecting the major organ systems (e.g.
central nervous system, heart, lungs). Aspects how molecular biology and biochemistry support molecular pharmacology will be addressed as well. regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail.
Now in its second edition, The Molecular Biology of Cancer: Mechanisms File Size: 84KB. Nitric oxide (NO) regulates diverse cellular signaling through S-nitrosylation of specific Cys residues of target intracellular level of S-nitrosoglutathione (GSNO), a major bioactive NO species, is regulated by GSNO reductase (GSNOR), a highly conserved master regulator of NO r, little is known about how the activity of GSNOR is by:.
Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Drawing on the latest research in this dynamic field, author Lauren Pecorino makes cutting-edge science readily : $Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.
Drawing on the latest research in this dynamic field, author Lauren Pecorino makes cutting-edge science readily accessible.It operates at various organizational levels, such as the molecular, subcellular, cellular, organ, and systemic platforms. Molecular pharmacology investigates the molecular mode of action of drugs, among others using genetic and molecular biology methods, and in consequence, it is one of the most rapidly developing fields of pharmacology.